The Maechler group reveals that type 2 diabetes is not just about insulin
Obesity, by promoting the resistance to the action of insulin is a major risk factor of type 2 diabetes. 听However, insulin imbalance may not be the only cause of the onset of diabetes.
In their study published in the , scientists of Prof. Pierre Maechler group have highlighted another mechanism: the liver appears to have the ability to produce a significant amount of glucose outside of any hormonal signal. In patients with excess liver fat, this overproduction of glucose could lead to type 2 diabetes, regardless of hormonal circuits. These results highlight a novel re-reading of the origin of diabetes in overweight patients.
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Mitochondria of liver cells by electronic microscopy. On the left, normal mice: mitochondria present an elongated shape. On the right, mice without the OPA1 protein: mitochondria present an altered globular form (from Figure 4 in Li et al. 2019 Journal of Biological Chemistry)
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Posted by: V茅ronique Rosset
30 Sept 2019