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A review on the modulation of calcium signaling by S-acylation

Calcium orchestrates vital cellular functions from embryonic development to adulthood, controlling processes such as neurotransmission and gene transcription. S-acylation, a lipid modification, is emerging as a key regulator of calcium handling proteins, altering their conformation and interactions. Perturbations in S-acylation disrupt calcium signalling and are implicated in diseases such as heart disease and cancer.

Interested to learn more?

To find out what is known and unknown about S-acylation's role in organelle and plasma membrane calcium transport proteins and its therapeutic potential for diseases rooted in calcium flux dysregulation, .

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