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Margitta Seeck studied medicine at Ludwigs-Maximilians AV¶ÌÊÓƵ in Munich, where she obtained her diploma and her MD. She then undertook post-doctoral studies in Berlin and at Harvard AV¶ÌÊÓƵ to further her knowledge of neurophysiology and epileptology, before joining the HUG. Since 1995, she heads the Geneva-Lausanne pre-surgical epilepsy programme, a national and international reference centre for difficult-to-treat epilepsy in adults and children, as well as the Epilepsy and EEG Unit in the HUG Division of Neurology.

Her research focuses on the analysis and localisation of cerebral electrical signals, the surgical assessment of epilepsy, seizure semiology and phenomena associated with cognitive epilepsy, epilepsy imaging and the neurology of first seizures. An expert for the Swiss Foundation and other national scientific foundations, and a former president of the Swiss Neurophysiology Society, she is actively involved in the teaching activities of the Swiss Neurophysiology Society. In 2018, she was the first woman to receive the prestigious Berger Prize in Epileptology and Clinical Neurophysiology, awarded by the International Federation of Clinical Neurophysiology (IFCN). This prize, awarded every four years, is in recognition of all the research she has carried out over the last 20 years in the field of epilepsy and electroencephalogram.  She is also a member of the Executive Committee of the International Federation of Clinical Neurophysiology (IFCN) and a member of the various task forces of the European Academy of Neurology (EAN). Appointed Associate Professor in the Department of Clinical Neurosciences at the UNIGE Faculty of Medicine in 2005, she was promoted to Full Professor in 2015 then appointed Emeritus Professor in October 2025.