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GROUPE LOEWITH

LABORATORY OF PROF. ROBBIE LOEWITH

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Our lab is interested in how cell growth is regulated via two protein complexes, TOR-complex 1 and 2, in response to nutrient levels and stresses. Using yeast as a model organism, we aim to:

- identify the molecular regulators upstream of the TOR complexes, primarily by using unbiased genetic screens (a traditional strong suit of yeast).

- identify new small-molecule inhibitors of the TOR complexes using state-of-the-art high-throughput screening.Ìý

- identify the effectors downstream of the TOR complexes by determining cellular responses after its inhibition via mass spectrometry and biochemical methods.

- determine the atomic structures of the TOR complexes, upstream regulators and downstream effectors by electron microscopy and X-ray crystallography.

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