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Development of in-situ optical spectroscopy tool to investigate molecular aggregation process toward phase transition and control the resulting self-assembled structure and function (molecular crystal, supramolecular assembly, amyloid fibril etc.).

Recherche en biologie marine, biologie cellulaire et biologie moléculaire

Chimie analytique, électrochimie, capteurs électrochimiques, principes de detection optique, optodes pour ions, capteurs exhaustives, conversion photoélectrique, extractions activée par lumière, réactifs nanosphériques, caractérisations de matériaux, polymères et modifications de polymères, analyses environnementales et biomédicales

Chemistry, spectroscopy and applications of surfaces, interfaces and chiral nanomaterials: Development and application of spectroscopic techniques to probe solid-liquid interfaces, preparation and applications of chiral nanomaterials, enantiodifferentiation, vibrational optical activity, self-assembly of plasmonic nanomaterials.

We want to understand in physical and molecular terms how cells talk to each other during development. This means our research is highly interdisciplinary: physics, cell biology, molecular biology, biochemistry, genetics... Indeed some of us in the lab are biologists, other physicists, chemists, engineers.

We are interested in the signaling events that control tissue growth: how is the shape and final size of a tissue achieved during embryogenesis?

We focus on two types of proliferation modes: growth control by morphogen gradients and asymmetric cell division in stem cells. We do this using two model systems: Drosophila and Zebrafish.

Molecular tools to study and pertub Hedgehog signaling and the primary cilium

Chimie analytique et spectrométrie de masse de petites molécules (composés organiques et pharmaceutiques) et de macromolécules (protéines). Imagerie par spectrométrie de masse, ionisation MS, MS haute résolution et acquisition en mode data indépendant, spectrométrie de masse à mobilité ionique, techniques séparatives et couplage MS, analyse de données, librairies MS, bioanalyse, métabolisme, toxicologie, metabolomics, lipidomics, protéomics, analyse quantitative ultra rapide. 

We study the molecular mechanisms of membrane traffic, especially clathrin-mediated endocytosis. We aim to understand the assembly, function and regulation of the complex molecular machineries that drive the formation of endocytic vesicles. Our main experimental organism is budding yeast. We use a combination of quantitative live-cell imaging, electron microscopy, genetics, biochemistry and structural biology.

We study the formation of spatial and temporal structures in individual biological cells and cells assemblies. The focus of our work is on theoretical descriptions of cytoskeletal dynamics. The cytoskeleton is a network of filamentous proteins, which is kept permanently out of thermodynamic equilibrium. It enables cells to divide, determines their shape and plays an important role in cell locomotion. In our descriptions, we rely heavily on concepts from non-linear dynamics and from non-equilibrium statistical mechanics.

Chimie organique de synthèse, chiralité et reconnaissance moléculaire: Réactivité organométallique et transformations asymétriques ; Applications synthétiques, physiques et biologiques de carbocations (chiraux) très stables ; Énantiodifférenciation RMN de substances chirales ; Chimie du phosphore hexacoordiné

Organic Synthesis, Supramolecular Chemistry, Bioorganic Chemistry, Functional Systems, Unorthodox Interactions

Synthèse, développement de méthodes, catalyse sélective, mécanisme de réaction

Research interests: Electrochemistry of metalloenzymes to study electron transfer and catalytic mechanisms for new biotechnologies.

Chimie supramoléculaire des éléments f.
Synthèse de matériaux polymétalliques luminescents et magnétiquement actifs. Thermodynamique des auto-assemblages. Molécules capables d'induire une conversion de lumière vers les hautes énergie (optique linéaire). Cristaux liquides luminescents thermotropes.

The focus of our group is to reach an in-depth theoretical understanding of regio- and enantion-selective processes.