Publications
Publications du groupe Meraldi
#contribution equale, §corresponding authorship
2024
Thomas A and Meraldi P Centrosome age breaks spindle size symmetry in cells thought to divide symmetrically
#Doria E, #Ivanova D, Thomas A and Meraldi P Transient lagging chromosomes cause primary microcephaly
2023
Dwivedi D, Harry D and Meraldi P Mild replication stress causes premature centriole dis-engagement via a sub-critical Plk1 activity under the control of ATR-Chk1
2022
#Castrogiovanni C, #Inchingolo AV, Harrison JU, Dudka D, Sen O, Burroughs NJ, §McAinsh AD and §Meraldi P Evidence for a HURP/EB free miced-nucleotide zone in kinetochore-microtubules,
§Castrogiovanni C and §Meraldi P Cell division: the science friction of chromosome attachment,
#Le Roux-Bourdieu M, #Dwivedi D, Harry D and Meraldi P. PLK1 controls centriole distal appendage formation and centrobin removal via independent pathways.
2021
Ducrey E, Castrogiovanni C, §Meraldi P and §Nowak-Sliwinska P Forcing dividing cancer cells to die; low-dose drug combinations to prevent spindle pole clustering.
2019
#Weiss A, #Le Roux Bourdieu M, Zoetmelk M, Ramzy GM, Rausch M, Harry D, Miljkovic-Licina M, Falamaki K, Wehrle-Haller B, Meraldi P and Nowak-Sliwinska P Identification of a synergistic multi-drug combination active in cancer cells via the prevention of spindle pole clustering
Bondaz A, Cirillo L, §Meraldi P and §Monica G Cell polarity dependent centrosome separation in the C. elegans embryo
Dudka D, Castrogiovanni C, Liaudet N, Vassal H and Meraldi P Spindle length-dependent HURP localization allows centrosomes to control kinetochore-fiber plus -end dynamics
#§Wilhelm T, #Olziersky A-M, Harry D, De Sousa F, Vassal H, Eskat A and §Meraldi P Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
Berndsen R, Castrogiovanni C, Weiss A, Rausch M, Dallinga M, Milijkovic-Licina M, Klaasen I, Meraldi P, van Beijnum J and Nowak-Sliwinska P Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression
Meraldi P Bub1 – the zombie protein that CRISPR cannot kill,
Guerreiro A and Meraldi P. AA344 and AA345 antibodies recognize the microtubule network in human cells by immunofluorescence.
2018
#Dudka D, #Noatynska A, Smith CA, Liaudet, N, McAinsh AD and Meraldi P. Complete microtubule-kinetochore occupancy favours segregation of merotlic attachments
#Olziersky AM, #Smith CA, Burroughs N, §McAinsh AD and §Meraldi P. Mitotic live cell imaging at different time scales
Lee BY, Schwager F, §Meraldi P and §Gotta M. p37/UBXN2B regulates spindle orientation by limiting cortical recruitment via PP1/Repo-Man
Labidy-Galy IS, Olivier T, Rodrigues M, Ferraioli D., Bodmer A, Petignat P, Rak B, Chopin N, Tredan O, Heudel PE, Stuckelberger S, Meeus P, Meraldi P, Viassolo V, Ayme A, Chappuis P, Stern MH, Houdayer C, Stoppa-Lyonnet D, Buisson A, Golmard L, Bonadona V and Ray-Coquad I. Location of mutations in BRCA2 gene and survival in patients with ovarian cancer
2017
#Gulluni F, #Martini M, #De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Meraldi P, Marchiò C, Pece S, Sapino A,Chiarle R, Di Fiore PP and Hirsch E. Mitotic spindle assembly and genomic stability in breast cancer require PIK3-C2a scaffolding function
Cirillo L, §Gotta M and §Meraldi P. The elephant in the room: role of microtubules in cancer. Book chapter in Cell Division Machinery and Disease,
Dudka D and Meraldi P. Symmetry does not come for free – cellular mechanisms to achieve a symmetric cell division. Book chapter in Asymmetric Cell Division in Development, Differentiation and Cancer,
Berndsen RH, Weiss A, Abdul UK, Wong TJ, Meraldi P, Griffioen AW, Dyson PJ, Nowak-Sliwinska P. Combination of ruthenium(II)-arene complex [Ru(η(6)-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity.
2016
Redli P, Gasic I, Meraldi P, Nigg EA, Santamaria A. The Ska complex promotes Aurora B activity to ensure chromosome biorientation.
Meraldi P. Centrosomes in spindle organization and chromosome segregation: a mechanistic view,
2015
Meraldi P. Two Ways to Get Mad at Kinetochores,
Gasic I, Nerurkar P and Meraldi P. Centrosome age regulates kinetochore microtubule stability and biases chromosome mis-segregation,
Tan CH, #Gasic I, #Huber-Reggi SP, Dudka D, Barisic M, Maiato H and Meraldi P. The equatorial position of the metaphase plate ensures symmetric cell divisions,
Mouysset J, Gilberto S, Meier MG, Lampert F, Belwal M, Meraldi P and Peter M. CRL4RBBP7 is required for efficient CENP-A deposition at centromeres,
2014
Chapard C, Meraldi P, Gleich T, Bachmann D, Hohl D, and Huber M. The TRAF-interacting protein TRAIP is a regulator of the spindle assembly checkpoint,
Maiolica A, De Medina Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganatgan S, Lou, HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R and Aebersold R. Modulation of the chromatin phosphoproteome by the Haspin protein kinase,
Turgay Y, Champion L, Balazs C, Held M, Toso A, Gerlich D, Meraldi P and Kutay U. SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown,
2013
#Vladimirou E, #Mchedlishvili N, #Gasic I, Samora CP, Armond JW, Holtackers R, §Meraldi P and §McAinsh AD. Non-autonomous movements of chromosomes in mitosis,
§Charnley M, Anderegg F, Holtackers R, Textor M and Meraldi P. Effect of cell shape and dimensionality on spindle orientation and mitotic timing,
Kress E, #SchwagerF, #Holtackers R, #Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer HH, Meraldi P and Gotta M. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A kinase,
Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KHA, Copenhaver GP, DeLuca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LET, Karpen G, Kops GJPL, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O’Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K and Cleveland DW. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant,
2012
Noatynska A, §Gotta M and §Meraldi P. Mitotic Spindle (Dis)orientation and DISease: cause or consequence, 2012,
Eskat A, Deng W, Hofmeister A, Rudolphi S, Emmerth S, Hellwig D, Ulbricht T, Döring V, Bancroft JM, McAinsh AD, Cardoso MC, Meraldi P, Hoischen C, Leonhardt H and Diekmann S. Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Subcomplex,
Wandke C, Barisic M, Sigl R, Rauch V, Wolf F, Amaro AC, Tan CH, Pereira AJ, Kutay U, Maiato H, Meraldi P and Geley S. Human chromokinesins promote congression and spindle microtubule dynamics during mitosis,
Logarinho E, Maffini S, Barisic M, Marques A, Toso A, Meraldi P and Maiato H. CLASPs ensure spindle pole integrity in response to kinetochore traction forces on congressing chromosomes.
#Mchedlishvili N, #Wieser S, Holtackers R, Moussyet J, Belwal M and Meraldi P. Kinetochores accelerate centrosome separation to ensure efficient alignment and segregation of chromosomes.
2011
Hagan R, Maniak MS, Buch HK, Meier MG, Meraldi P, §Shah JS, §Sorger PK. p31comet acts to ensure timely checkpoint silencing subsequent to kinetochore attachment.
Hellwig D, Emmerth S, Ulbricht T, Doering V, Hoischen C, Martin R, Samora C, McAinsh AD, Carroll C, Straight A, Meraldi P and Diekmann S. Dynamics of CENP-N kinetochore binding during the cell cycle.
Meraldi P. Keeping Kinetochores on track.
§McAinsh AD and §Meraldi P. The CCAN complex: linking centromere specification to control of kinetochore microtubule-dynamics.
§De Medina-Redondo M and §Meraldi P. The spindle assembly checkpoint: clock or domino?
Thoma C, Toso A, Meraldi P and Krek W. Mechanisms of aneuploidy and its suppression by tumor suppressor proteins.
2010
Amaro AC, Samora C, Holtackers R, Wang E, Kingston IJ, Alonso M, Lampson M, §McAinsh AD, §Meraldi P. Molecular control of kinetochore-microtubule dynamics and chromosome oscillations.
#Jaqaman K, #King EM, #Amaro AC, #Winter JR, Dorn J, Elliot H, Mchedlishvili N, McClelland S, Porter IM, Posch M, Toso A, §Danuser G, §McAinsh AD, §Meraldi P and §Swedlow JR. Quantitative 4D live-cell imaging reveals regulation of kinetochore alignment within the metaphase plate by centromere stiffness and microtubule depolymerases.
§Kops GJPL, Saurin AT and §Meraldi P. Finding the middle ground: How kinetochores power chromosome congression.
2009
#Thoma CR, #Toso A, Gutbordt KL, Reggi SP, Frew IJ, Schraml P, Hergovich A, Moch H, §Meraldi P and §Krek W. VHL loss causes spindle mis-orientation and chromosome instability.
Klebig C, Korinth D and Meraldi P. Bub1 regulates chromosome segregation in a kinetochore independent manner.
#Toso A, #Winter JR, Garrod AJ, Amaro AC, §Meraldi Pand §McAinsh AD. Kinetochores-generated pushing forces separate centrosomes during bipolar spindle assembly.
Thoma C, Toso A, §Meraldi P and §Krek W. Double-trouble in mitosis caused by von Hippel-Lindau tumour suppressor protein inactivation.
De Medina-Redondo M and Meraldi P. A life outside kinetochores for Bub1 kinases?
Amaro AC and Meraldi P. COMA puts Ipl1-Sli15 at the right spot.
Klebig C, Toso A, Borusu S and Meraldi P. Probing kinetochore function: spindle checkpoint and chromosome congression.
2007
#McClelland SE, #Borusu S, Amaro AC, Winter JR, Belwal M, §McAinsh AD and §Meraldi P. The CENP-ANAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity.
2006
§#McAinsh AD, §#Meraldi P, #Draviam VM, Toso A and Sorger PK. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation.
#Meraldi P, #McAinsh AD, Rheinbay E and Sorger PK. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins.
Publications as pre-and post-doctoral researcher
#equal contribution
2005
Meraldi P and Sorger PK. A dual role for Bub1 in the spindle checkpoint and chromosome congression.
Rapley J, Baxter JE, Wattam SL, Casenghi M, Meraldi P, Nigg EA, and Fry AM. Coordinate regulation of the mother centriole component Nlp by Nek2 and Plk1 protein kinases.
2004
#Meraldi P, #Draviam VM and Sorger PK. Timing and checkpoint in the regulation of mitotic progression.
Meraldi P, Honda R and Nigg EA. Aurora kinases link chromosome segregation and cell division to cancer susceptibility.
2003
#Casenghi M, #Meraldi P, Weinhart U, Duncan PI, Koerner R, and Nigg EA. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
2002
Meraldi P and Nigg EA The centrosome cycle.
Kufer TA, Sillje HH, Koerner R, Gruss OJ, Meraldi P and Nigg EA. Human TPX2 is required for targeting Aurora-A kinase to the spindle.
Meraldi P, Honda R and Nigg EA. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(-/-) cells.
2001
Meraldi P, and Nigg EA. Centrosome cohesion is regulated by a balance of kinase and phosphatase activities.
1999
Mayor T, Meraldi P, Stierhof YD, Nigg EA and Fry AM. Protein kinases in control of the centrosome cycle.
Meraldi P, Lukas J, Fry AM, Bartek J and Nigg EA. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-Cyclin A.
1998
Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K and Nigg EA. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.
Fry AM, Meraldi P and Nigg EA. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.