Targeting Cytokine Secreting Lymphocytes (TCSL)
Dr Jandus main scientific interest is in the study of T cell- and Innate Lymphoid Cell (ILC)- mediated immune responses to human tumors. She has adopted and developed cutting-edge technologies for high-throughput analyses of T cells, at the single cell level, allowing to focus on the quantitative and qualitative evaluation of natural and therapy-induced tumor-specific CD4 T cell responses. She aims to identify the most potent T cells and best-of-class T cell receptors (TCRs), enabling their rapid and cost-effective isolation and validation in clinical trials. In parallel, she is investigating the role of Innate lymphoid cell (ILC) subsets, a recently described family of innate immune effector cells, in the context of anti-tumor immunity. She has been pioneering in reporting the pro-tumoral role of the ILC2 subset in human tumors and she is currently developing strategies to target these cells therapeutically in patients.
Specific expertise
- Multiparamtric, flow-cytometry based human Innate and adaptive lymphocyte profiling
- Single-cell nanobiosensors
- Immunotherapy
Selected publications
Trabanelli S, Ercolano G, Wyss T, Gomez-Cadena A, Falquet M, Cropp D, Imbratta C, Leblond MM, Salvestrini V, Curti A, Adotevi O, Jandus C* & Verdeil G*. . EMBO, 2022 Jun 14;41(12):e109300. *Shared last authorship
Ercolano G, Gomez-Cadena A, Dumauthioz N, Vanoni G, Kreutzfeldt M, Wyss T, Michalik L, Loyon R, Ianaro A, Ho P-C, Borg C, Kopf M, Merkler D, Krebs P, Romero P, Trabanelli S and听Jandus C.听.听Nat Communications, 2021 May; 12(1):2538
Cachot听A, Bilous听M,听Liu Y-C, Li听X,听Saillard听M, Cenerenti听M, Rockinger听GA, Wyss听T, Guillaume听P, Schmidt听J, Genolet听R, Ercolano听G, Protti听MP, Reith听W, Ioannidou听K, de Leval听L, Trapani听JA, Coukos听G, Harari听A, Speiser听DE,听听Mathis听A, Gfeller听D, Altug听H, Romero听P and听Jandus听C.听听Science Adv, 2021 Feb, 7(9):eabe3348
Rockinger AG., Guillaume P., Cachot A., Saillard M., Speiser DE., Coukos G., Harari A., Romero P., Schmidt J. and Jandus C. JITC, 2020 May, 8(1):e000435
Trabanelli S, Chevalier MF, Martinez-Usatorre A, Gomez-Cadena A, Salom茅 B, Lecciso M, Salvestrini V, Verdeil G, Racle J, Papayannidis C, Morita H, Pizzitola I, Grandcl茅ment C, Bohner P, Bruni E, Girorta M, Pallavi R, Falvo P, Leibundgut EO, Baerlocher GM, Carlo-Stella C, Taurino D, Santoro A, Spinelli O, Rambaldi A, Giarin E, Basso G, Tresoldi C, Ciceri F, Gfeller D, Akdis CA, Mazzarella L, Minucci S, Pelicci PG, Marcenaro E, McKenzie ANJ, Vanhecke D, Coukos G, Mavilio D, Curti A, Derr茅 L and Jandus C. Nat Commun, 2017 Sep, 8(1):593
7 Apr 2022