Recognition, phagocytosis and killing of bacteria
The main research objectives of Professor Pierre Cosson's laboratory focus on the links between intracellular transport and immunology. He studies how phagocytic cells ingest and eliminate bacteria, pathogenic or not, using Dictyostelium as a model organism. The molecular mechanisms involved in bacterial clearance remain poorly understood, and his goal is to identify them, determine their quantitative significance and assess their specificity against different bacteria. In addition, his team is investigating how pathogenic bacteria evade being eliminated by phagocytes.
SPECIFIC EXPERTISE
This research group uses the amoeba Dictyostelium discoideum as a model system because of its similarity to mammalian phagocytic cells. They study various gene products involved in phagocytosis, with the aim of elucidating the processes of recognition, ingestion and intracellular elimination of bacteria. In addition, they study the bacterial survival strategies employed by pathogens such as Pseudomona aeruginosa, Klebsiella pneumoniae and Mycobacterium marinum, with the ultimate goal of understanding host-pathogen relationships.
In addition, Pierre Cosson's group is recognised for its contributions to the development of alternatives to animal experimentation, particularly in the field of antibody research. They have pioneered the use of recombinant antibodies and have created resources such as the , the Geneva Antibody Facility and the journal , dedicated to describing and characterising recombinant antibodies.
Key PUBLICATIONS
-Ayadi I, Lamrabet O, Munoz-Ruiz R, Jauslin T, Guilhen C, Cosson P. 2024. . Mol. Microb. 121: 69-84.
-Crespo-Yanez, X., Oddy, J., Lamrabet, O., Jauslin, T., Marchetti, A., Cosson, P. 2023. . Mol. Microbiol. 119:74-85.
-Jauslin,T., Lamrabet, O., Crespo-Yañez, X., Marchetti, A., Ayadi, I., Ifrid, E., Guilhen, C., Leippe, M., Cosson, P. 2021. . mBio 12: e03169-20.
-Bodinier, R., Leiba, J., Sabra A., Jauslin T.N., Lamrabet O., Guilhen C., Marchetti A., Iwade Y., Kawata T., Lima W.C., Cosson P. 2019. . Cell Microbiol. e13129.
-Lelong, E., Marchetti, A., Guého, A., Lima, W.C., Sattler, N., Molmeret, M., Hagedorn, M., Soldati, T., Cosson, P. 2011. . Cell. Microb. 13:246-58.
19 Mar 2024