Biophysics and Cell Biology of Signaling
We want to understand in physical and molecular terms how cells talk to each other during development. This means our research is highly interdisciplinary: physics, cell biology, molecular biology, biochemistry, genetics... Indeed some of us in the lab are biologists, other physicists, chemists, engineers or mathematicians.
We are interested in the signaling events that control tissue growth: how is the shape and final size of a tissue achieved during embryogenesis?
We focus on two types of proliferation modes: growth control by morphogen gradients and asymmetric cell division in stem cells. We do this using two model systems: Drosophila and Zebrafish.
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Key Publications:
- Romanova Michailidi, M.; Hadjivasiliou, Z.; Aguilar-Hidalgo, D.; Basagiannis, D.; Seum, C.; Dubois-Barthelemy, M.; J眉licher, F.; Gonzalez Gaitan, M.听.听Nature听2021. .
- Derivery, E.; Seum, C.; Daeden, A.; Loubery, S. P.; Holtzer, L. H.; J眉licher, F.; Gonzalez Gaitan, M.听.听Nature听2015,听528听(7581), 280-285.
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- Wartlick, O.; Mumcu, P.; Kicheva, A. K.; Bittig, T.; Seum, C.; Julicher, F.; Gonzalez Gaitan, M.听.听Science听2011,听331听(6021), 1154-1159. .
- Coumailleau, Franck; F眉rthauer, Maximilian; Knoblich, J. A.; Gonz谩lez-Gait谩n, Marcos (2009)听Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division.听.
- Kicheva, Anna; Pantazis, Periklis; Bollenbach, Tobias; Kalaidzidis, Yannis; Bittig, Thomas; Julicher, Frank; Gonzalez-Gaitan, Marcos (2007)听Kinetics of Morphogen Gradient Formation.听.
- Martinez Merino, M.; Seum, C.; Dubois, M.; Gonzalez Gaitan, M.听.听Nature cell biology听2022. .
- Mateus Domingos, R.; Holtzer, L. H.; Seum, C.; Hadjivasiliou, Z.; Dubois-Barthelemy, M.; J眉licher, F.; Gonzalez Gaitan, M.听.听Cell Reports听2020,听30听(12), 4292-4302. .
- Castanon Ortega, I.; Hannich, J. T.; Abrami, L.; Huber, F.; Dubois, M.; Muller, M. J.; van der Goot, F. G.; Gonzalez Gaitan, M.听.听Nature Communications2020,听11听(3317). .
- Aguilar-Hidalgo, D.; Werner, S.; Wartlick, O.; Gonzalez Gaitan, M.; Friedrich, B. M.; J眉licher, F.听.听Physical Review Letters听2018,听120听(198102). .
- Kressmann, S.; Campos Ramos, C.; Castanon Ortega, I.; Fuerthauer, M.; Gonzalez Gaitan, M.听.听Nature Cell Biology听2015,听17听(3), 333-339. .